Knockdown of apoptosis-inducing factor disrupts function of respiratory complex
نویسندگان
چکیده
منابع مشابه
Knockdown of apoptosis-inducing factor disrupts function of respiratory complex I.
Recent findings suggest that apoptotic protein apoptosis-inducing factor (AIF) may also play an important non-apoptotic function inside mitochondria. AIF was proposed to be an important component of respiratory chain complex I that is the major producer of superoxide radical. The possible role of AIF is still controversial. Superoxide production could be used as a valuable measure of complex I ...
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Although the seminal paper by Kerr, Wyllie and Currie (Kerr et al., 1972), who coined the word ‘apoptosis’, stated that only nuclei but not cytoplasmic organelles would undergo major modifications in the dying cell, recent evidence suggests that no cellular compartment is spared (Ferri and Kroemer, 2001). Mitochondria are particularly affected early during the apoptotic process, and they are no...
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ژورنال
عنوان ژورنال: BIOCELL
سال: 2012
ISSN: 1667-5746
DOI: 10.32604/biocell.2012.36.121